A Single-Nucleotide Polymorphism Upstream of the HLA-C Locus Is Associated With an Anti–Hepatitis C Virus–Seronegative State in a High-Risk Exposed Cohort. (9th August 2018)

• Record Type: Journal Article
• Authors: Thoens, Christine; Heinold, Andreas; Lindemann, Monika; Horn, Peter A; Chang, Dae-In; Scherbaum, Norbert; Timm, Joerg; Heinemann, Falko M
• Is Part Of: Journal of infectious diseases. Volume 218:Number 12(2018)
• Page Start: 2016
• Page End: 2019
• Publication Date: 2018-08-09
• Subjects: HCV infection -- rs9264942 polymorphism -- HLA-C1/C1 -- people who inject drugs -- NK cells; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiy492
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: In this study, we examined the impact of the rs9264942 single-nucleotide polymorphism, previously shown to be associated with human immunodeficiency virus infection status and HLA-C expression, on the hepatitis C virus status in 359 people who inject drugs (PWID). The linkage of rs9264942 alleles to HLA-C antigens assigned to different expression levels was confirmed. Multivariate analysis revealed the age ( P = .003) and the rs9264942 genotype ( P = .006) to be independent factors for the classification to the PWID groups. Our study showed that the presence of the rs9264942 C/C genotype was associated with persistent seronegativity.