HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D. (19th December 2017)

• Record Type: Journal Article
• Authors: Shiels, Meredith S; Kirk, Gregory D; Drummond, M Bradley; Dhillon, Dilsher; Hanash, Samir M; Taguchi, Ayumu; Engels, Eric A
• Is Part Of: Journal of infectious diseases. Volume 217:Number 3(2018)
• Page Start: 413
• Page End: 417
• Publication Date: 2017-12-19
• Subjects: HIV -- lung -- inflammation -- surfactant protein; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jix510
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract : People with HIV manifest elevated serum levels of prosurfactant protein B compared to HIV-uninfected people, and levels are further increased in association with declining CD4 cell count, high HIV RNA, and in the absence of HIV treatment, independent of tobacco use. Abstract: Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts ( P trend = .001), higher HIV RNA ( P trend = .05), and without highly active antiretroviral therapy ( P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.