MiR-23b-3p induces the proliferation and metastasis of esophageal squamous cell carcinomas cells through the inhibition of EBF3. (10th May 2018)

• Record Type: Journal Article
• Authors: Zhang, Jing; Zhang, Yan; Tan, Xiaoping; Zhang, Qing; Liu, Chaoyong; Zhang, Yali
• Is Part Of: Acta biochimica et biophysica Sinica. Volume 50:Number 6(2018:Jun.)
• Page Start: 605
• Page End: 614
• Publication Date: 2018-05-10
• Subjects: miR-23b-3p -- EBF3 -- epithelial-to-mesenchymal transition (EMT) -- esophageal squamous cell carcinoma (ESCC); Biochemistry -- Periodicals; Biophysics -- Periodicals; 572.05
• DOI: 10.1093/abbs/gmy049
• Languages: English
• ISSNs: 1672-9145

Abstract

Abstract: MicroRNAs (miRNAs), some small non-coding RNAs that regulate gene expression at the posttranscriptional level, are always aberrantly expressed in carcinomas. In this study, we found that miR-23b-3p was remarkably up-regulated in human esophageal squamous cell carcinoma cells and tissues. Moreover, miR-23b-3p could induce the proliferation, invasion, and metastasis in vitro . EBF3 was identified as the direct downstream target gene of miR-23b-3p and ectogenic EBF3 could strongly inhibit the proliferation, invasion, and metastasis in vitro . Furthermore, it was found that miR-23b-3p could regulate epithelial-to-mesenchymal transition progress by blocking EBF3. Therefore, it was concluded that miR-23b-3p targeted EBF3 to accelerate the proliferation, invasion, and metastasis in ESCC.