Original Antigenic Sin Shapes the Immunological Repertoire Evoked by Human Cytomegalovirus Glycoprotein B/MF59 Vaccine in Seropositive Recipients. (27th February 2019)

• Record Type: Journal Article
• Authors: Baraniak, Ilona; Kern, Florian; Holenya, Pavlo; Griffiths, Paul; Reeves, Matthew
• Is Part Of: Journal of infectious diseases. Volume 220:Number 2(2019)
• Page Start: 228
• Page End: 232
• Publication Date: 2019-02-27
• Subjects: cytomegalovirus -- vaccination -- antibody responses -- original antigenic sin; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiz089
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: A human cytomegalovirus (HCMV) vaccine is urgently needed to protect against primary infection and enhance existing immunity in HCMV-infected individuals (HCMV + ). Using sera from HCMV + glycoprotein B/MF59 vaccine recipients prior to transplant, we investigated the composition of the immune response. Vaccination boosted preexisting humoral responses in our HCMV + cohort but did not promote de novo responses against novel linear epitopes. This suggests that prior natural infection has a profound effect on shaping the antibody repertoire and subsequent response to vaccination ("original antigenic sin"). Thus, vaccination of HCMV + may require strategies of epitope presentation distinct from those intended to prevent primary infection. Abstract : Vaccination of human cytomegalovirus–infected individuals with the glycoprotein B (gB) vaccine boosts preexisting immune responses against gB but fails to induce new responses against novel linear epitopes within gB in seropositive individuals.