Biodegradable Electrosprayed NPs as Drug Carriers for Optimal Treatment of Orthopaedic Infections. (2019)

• Record Type: Journal Article
• Authors: Tsiapla, A.R.; Bakola, V.; Karagkiozaki, V.; Pavlidou, E.; Logothetidis, S.
• Is Part Of: Materials today. Volume 19:Part 1(2019)
• Page Start: 110
• Page End: 116
• Publication Date: 2019
• Subjects: Electrospraying -- Nanoparticles -- Drug Delivery -- Nanocoatings -- Orthopaedics; Materials science -- Congresses -- Periodicals; 620.1
• DOI: 10.1016/j.matpr.2019.07.665
• Languages: English
• ISSNs: 2214-7853

Abstract

Abstract: The possibility of replacing the damaged joint by an artificial (hip replacement) is one of the most important achievements of the orthopaedic science because it enables the person suffering from osteoarthritis to regain a normal life. However, infections that can be created after an implantation are one of the major complications that can lead to implant failure. Therefore, a preliminary study of vancomycin drug loaded Polycaprolactone (PCL) nanoparticles were created via Electrospraying Process, making it a promising nanovehicle to prevent and treat orthopedic implant-associated infections. Scanning Electron Microscopy (SEM) measurements confirmed the successful fabrication of these structures. Finally, drug release kinetics was established to observe the sustained release of the drug and degradation studies were performed in order to evaluate the mass loss of polymers.