Automated and objective removal of bifurcation aneurysms: Incremental improvements, and validation against healthy controls. (11th November 2019)

• Record Type: Journal Article
• Authors: Bergersen, Aslak W.; Chnafa, Christophe; Gallo, Diego; Piccinelli, Marina; Steinman, David A.; Valen-Sendstad, Kristian
• Is Part Of: Journal of biomechanics. Volume 96(2019)
• Publication Date: 2019-11-11
• Subjects: Mechanobiology -- Wall shear stress -- Wall shear stress gradients -- Aneurysm pathogenesis -- Subarachnoid hemorrhage; Animal mechanics -- Periodicals; Biomechanics -- Periodicals; Biomechanics -- Periodicals; Mécanique animale -- Périodiques; Biomécanique -- Périodiques; Electronic journals; 571.4305
• DOI: 10.1016/j.jbiomech.2019.109342
• Languages: English
• ISSNs: 0021-9290

Abstract

Abstract: Abnormal hemodynamic stresses are thought to correlate with aneurysm initiation, growth, and rupture. We have previously investigated the role of wall shear stress (WSS) and WSS gradients (WSSG) in search for a mechanistic link to formation of sidewall aneurysms using an automated and objective tool for aneurysm removal and arterial reconstruction in combination with computational fluid dynamics (CFD). However, we warned against the use of the tool for bifurcation type aneurysms because of a potential unrealistic reconstruction of the apex. We hypothesized that inclusion of additional morphological features from the surrounding vasculature could overcome these constraints. We extended the previously published method for removal and reconstruction of the bifurcation vasculature based on diverging and converging points of the parent and daughter artery centerlines, to also include two new centerlines between the daughter vessels, one of them passed through the bifurcation center. Validation was performed by comparing the efficacy of the two algorithms, using ten healthy models of the internal carotid artery terminus as ground truth. Qualitative results showed that the bifurcation apexes became smoother relative to the original algorithm; more consistent with the reference models. This was reflected quantitatively by a reduced maximum distance between the reference and reconstructed surfaces, although not statistically significant. Furthermore, the modified algorithm also quantitatively improved CFD derived WSS and WSSG, especially the latter. In conclusion, the modified algorithm does not perfectly reconstruct the bifurcation apex, but provides an incremental improvement, especially important for the derived hemodynamic metrics of interest in vascular pathobiology.