No association between circulating concentrations of vitamin D and risk of lung cancer: an analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3). (2nd April 2018)

• Record Type: Journal Article
• Authors: Muller, D C; Hodge, A M; Fanidi, A; Albanes, D; Mai, X M; Shu, X O; Weinstein, S J; Larose, T L; Zhang, X; Han, J; Stampfer, M J; Smith-Warner, S A; Ma, J; Gaziano, J M; Sesso, H D; Stevens, V L; McCullough, M L; Layne, T M; Prentice, R; Pettinger, M; Thomson, C A; Zheng, W; Gao, Y T; Rothman, N; Xiang, Y B; Cai, H; Wang, R; Yuan, J M; Koh, W P; Butler, L M; Cai, Q; Blot, W J; Wu, J; Ueland, P M; Midttun, Ø; Langhammer, A; Hveem, K; Johansson, M; Hultdin, J; Grankvist, K; Arslan, A A; Le Marchand, L; Severi, G; Johansson, M; Brennan, P;
• Is Part Of: Annals of oncology. Volume 29:Number 6(2018)
• Page Start: 1468
• Page End: 1475
• Publication Date: 2018-04-02
• Subjects: serum 25-hydroxyvitamin D -- vitamin D -- lung cancer -- case–control -- prospective -- consortium; Oncology -- Periodicals; 616.992
• DOI: 10.1093/annonc/mdy104
• Languages: English
• ISSNs: 0923-7534

Abstract

Abstract: Background: There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in prediagnostic blood from 20 cohorts participating in the Lung Cancer Cohort Consortium (LC3). Patients and methods: The study included 5313 lung cancer cases and 5313 controls. Blood samples for the cases were collected, on average, 5 years before lung cancer diagnosis. Controls were individually matched to the cases by cohort, sex, age, race/ethnicity, date of blood collection, and smoking status in five categories. Liquid chromatography coupled with tandem mass spectrometry was used to separately analyze 25-hydroxyvitamin D2 [25(OH)D2 ] and 25-hydroxyvitamin D3 [25(OH)D3 ] and their concentrations were combined to give an overall measure of 25(OH)D. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for 25(OH)D as both continuous and categorical variables. Results: Overall, no apparent association between 25(OH)D and risk of lung cancer was observed (multivariable adjusted OR for a doubling in concentration: 0.98, 95% CI: 0.91, 1.06). Similarly, we found no clear evidence of interaction by cohort, sex, age, smoking status, or histology. Conclusion: This study did not support an association between vitamin D concentrations and lung cancer risk.