Evaluation of the added value of 1H-magnetic resonance spectroscopy for the diagnosis of pediatric brain lesions in clinical practice. Issue 1 (13th May 2017)

• Record Type: Journal Article
• Authors: Manias, Karen; Gill, Simrandip K; Zarinabad, Niloufar; Davies, Paul; English, Martin; Ford, Daniel; MacPherson, Lesley; Nicklaus-Wollenteit, Ina; Oates, Adam; Solanki, Guirish; Adamski, Jenny; Wilson, Martin; Peet, Andrew C
• Is Part Of: Neuro-oncology practice. Volume 5:Issue 1(2018)
• Page Start: 18
• Page End: 27
• Publication Date: 2017-05-13
• Subjects: 1H magnetic resonance spectroscopy (MRS) -- magnetic resonance imaging (MRI) -- metabolite profiles -- noninvasive diagnosis -- pediatric brain tumors; Brain -- Tumors -- Periodicals; Brain -- Cancer -- Periodicals; Nervous system -- Cancer -- Periodicals; 616.99481005
• DOI: 10.1093/nop/npx005
• Languages: English
• ISSNs: 2054-2577

Abstract

Abstract: Background: Magnetic resonance spectroscopy (MRS) aids noninvasive diagnosis of pediatric brain tumors, but use in clinical practice is not well documented. We aimed to review clinical use of MRS, establish added value in noninvasive diagnosis, and investigate potential impact on patient care. Methods: Sixty-nine children with lesions imaged using MRS and reviewed by the tumor board from 2014 to 2016 met inclusion criteria. Contemporaneous MRI diagnosis, spectroscopy analysis, histopathology, and clinical information were reviewed. Final diagnosis was agreed on by the tumor board at study end. Results: Five cases were excluded for lack of documented MRI diagnosis. The principal MRI diagnosis by pediatric radiologists was correct in 59%, increasing to 73% with addition of MRS. Of the 73%, 19.1% (95% CI, 9.1%-33.3%) were incorrectly diagnosed with MRI alone. MRS led to a significant improvement in correct diagnosis over all tumor types ( P = .012). Of diagnoses correctly made with MRI, confidence increased by 37% when adding MRS, with no patients incorrectly re-diagnosed. Indolent lesions were diagnosed noninvasively in 85% of cases, with MRS a major contributor to 91% of these diagnoses. Of all patients, 39% were managed without histopathological diagnosis. MRS contributed to diagnosis in 68% of this group, modifying it in 12%. MRS influenced management in 33% of cases, mainly through avoiding and guiding biopsy and aiding tumor characterization. Conclusion: MRS can improve accuracy and confidence in noninvasive diagnosis of pediatric brain lesions in clinical practice. There is potential to improve outcomes through avoiding biopsy of indolent lesions, aiding tumor characterization, and facilitating earlier family discussions and treatment planning.