Radiation Responses of Human Mesenchymal Stem Cells Derived From Different Sources. Issue 4 (6th December 2019)

• Record Type: Journal Article
• Authors: He, Ningning; Xiao, Changyan; Sun, Yuxiao; Wang, Yan; Du, Liqing; Feng, Yu; Liu, Yang; Wang, Qin; Ji, Kaihua; Wang, Jinhan; Zhang, Manman; Xu, Chang; Liu, Qiang
• Is Part Of: Dose-response. Volume 17:Issue 4(2019:Oct./Dec.)
• Publication Date: 2019-12-06
• Subjects: mesenchymal stem cells (MSCs) -- ionizing radiation -- radiation resistance -- biomarker; Dose-response relationship (Biochemistry) -- Periodicals; Drugs -- Dose-response relationship -- Periodicals; Drugs -- Physiological effect -- Periodicals; Hormesis -- Periodicals; Dose-Response Relationship, Drug -- Periodicals; Dose-response relationship (Biochemistry); Drugs -- Dose-response relationship; Drugs -- Physiological effect; Periodicals; 571.634
• DOI: 10.1177/1559325819893210
• Languages: English
• ISSNs: 1559-3258

Abstract

Mesenchymal stem cells (MSCs) derived from different tissues may aid in the regeneration of radiation-induced organ lesions; however, the radiation responses of human MSCs from different sources are unknown. In our study, a comparison of the results from cell proliferation, apoptosis, cell cycle, DNA damage, and DNA repair assays consistently showed that MSCs derived from adipose tissue possess a significantly stronger radiation resistance capacity than MSCs derived from umbilical cord and gingival, which is accompanied by a higher level of phosphorylated signal transducer and activator of transcription 3 (Stat3) expression. This reminds us Stat3 could be a potential biomarker of radiation resistance. These findings provide a better understanding of radiation-induced biologic responses in MSCs and may lead to the development of better strategies for stem cell treatment and cancer therapy.