EEG cross-frequency correlations as a marker of predisposition to affective disorders. Issue 11 (November 2019)

• Record Type: Journal Article
• Authors: Knyazev, Gennady G.; Savostyanov, Alexander N.; Bocharov, Andrey V.; Aftanas, Lyubomir I.
• Is Part Of: Heliyon. Volume 5:Issue 11(2019)
• Publication Date: 2019-11
• Subjects: Neuroscience -- Emotion -- Mental disorder -- Physiology -- Biological psychiatry -- Depression -- Individual differences -- Stress -- 5-HTTLPR -- Cross-frequency correlations -- Personality -- Source-level analysis -- EEG -- Major depressive disorder; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2019.e02942
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: EEG cross-frequency amplitude-amplitude correlation (CF-AAC) has been considered as a potential marker of social anxiety and other affective disturbances. Functional significance of this phenomenon remains unclear, partly because the majority of studies used channel-level analysis, which precluded the spatial localization of observed effects. It is not also clear whether CF-AAC may serve as a marker of specific pathological conditions and specific states, or a more general predisposition to affective disturbances. We used source-level analysis of EEG data obtained in resting conditions in a nonclinical sample and patients with major depressive disorder (MDD) and investigated associations of CF-AAC measures with a broad range of known risk factors for affective disorders, including age, gender, genotype, stress exposure, personality, and self-reported 'neurotic' symptomatology. A consistent pattern of associations showed that all investigated risk factors were associated with an enhancement of CF-AAC in cortical regions associated with emotional and self-referential processing. It could be concluded that CF-AAC is a promising candidate marker of a general predisposition to affective disorders at preclinical stages. Abstract : Neuroscience; Emotion; Mental disorder; Physiology; Biological psychiatry; Depression; Individual differences; Stress; 5-HTTLPR; Cross-frequency correlations; Personality; Source-level analysis; EEG; Major depressive disorder