Prognostic factors for the sequelae and severity of Guillain‐Barré syndrome in children. Issue 6 (23rd October 2019)

• Record Type: Journal Article
• Authors: Estrade, Sophie; Guiomard, Clara; Fabry, Vincent; Baudou, Eloise; Cances, Claude; Chaix, Yves; Cintas, Pascal; Meyer, Pierre; Cheuret, Emmanuel
• Is Part Of: Muscle & nerve. Volume 60:Issue 6(2019)
• Page Start: 716
• Page End: 723
• Publication Date: 2019-10-23
• Subjects: children -- dysautonomia -- Guillain‐Barré syndrome -- outcome -- sequelae; Neuromuscular diseases -- Periodicals; Muscles -- Periodicals; Nerves -- Periodicals; 616.74
• DOI: 10.1002/mus.26706
• Languages: English
• ISSNs: 0148-639X

Abstract

Abstract: Introduction: Guillain‐Barré syndrome (GBS) is an inflammatory polyradiculoneuritis. Our aim in this study was to describe the clinical characteristics and the long‐term sequelae of GBS in a French pediatric population. Methods: In this multicenter, retrospective study we evaluated clinical signs, radiological examinations, laboratory tests, treatments, and outcomes. Results: One hundred ten children were included in this investigation. These children presented with walking difficulties, muscle weakness, and cranial nerve impairment. Electrodiagnostic testing revealed 70% with acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and 16% with acute motor axonal neuropathy (AMAN). One hundred children received immunoglobulins. At follow‐up, 77% were cured, whereas 9% had sequelae, associated with an axonal form ( P < .01) and a short interval between symptom onset and hospitalization ( P < .01). The need for intubation was correlated with peripheral facial paralysis ( P < .01) and dysautonomia ( P < .01). Discussion: Although AIDP and AMAN present in a similar way, the axonal form is associated with a worse outcome.