Wound Complications in Head and Neck Squamous Cell Carcinomas After Anti–PD‐1 Therapy. (10th May 2019)

• Record Type: Journal Article
• Authors: Hwang, Victoria; Mendez, Eduardo; Chow, Laura Q. M.; Futran, Neal David; Andersen, Peter; Li, Ryan; Divi, Vasu; Rodriguez, Cristina P.
• Is Part Of: Laryngoscope. Volume 129:Number 12(2019)
• Page Start: E428
• Page End: E433
• Publication Date: 2019-05-10
• Subjects: Head and neck cancer -- head and neck squamous cell carcinoma -- immunotherapy -- checkpoint inhibitors -- osteoradionecrosis -- monoclonal antibodies; Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.27902
• Languages: English
• ISSNs: 0023-852X

Abstract

Abstract : Immune checkpoint inhibitors have demonstrated activity in recurrent/metastatic head and neck squamous cell cancer, but less is known regarding their long‐term sequelae. We describe four patients who, after complete responses to anti–PD‐1 therapy, developed complications requiring surgical intervention. Patient 1 is a 57‐year‐old female whose marked tumor regression exposed some mandibular hardware. Patient 2 is a 39‐year‐old male who developed an ulcerated buccal lesion with exposed mandible. Patient 3 is a 66‐year‐old male with craniofacial osteoradionecrosis. Patient 4 is a 71‐year‐old male who developed an exposed and fractured mandible. All patients successfully underwent surgical intervention and remain disease free. Laryngoscope, 129:E428–E433, 2019