New approach to the synthesis of substituted 7H‐furo[3, 2‐b]pyran‐7‐ones based on 5‐hydroxy‐2‐methyl‐4H‐pyran‐4‐one derivatives. (3rd September 2019)

• Record Type: Journal Article
• Authors: Komogortsev, Andrey N.; Lichitsky, Boris V.; Tretyakov, Alexander D.; Fakhrutdinov, Artem N.; Dudinov, Arkady A.; Krayushkin, Michail M.
• Is Part Of: Journal of heterocyclic chemistry. Volume 56:Number 11(2019)
• Page Start: 3081
• Page End: 3087
• Publication Date: 2019-09-03
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.3706
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : A convenient approach to the synthesis of the previously unknown 7 H ‐furo[3, 2‐ b ]pyran‐7‐ones based on the intramolecular cyclization of carbonyl derivatives of 5‐hydroxy‐2‐methyl‐4 H ‐pyran‐4‐one has been elaborated. Key intermediates in the synthesis of the target 7 H ‐furo[3, 2‐ b ]pyran‐7‐ones are 3‐hydroxy‐6‐methyl‐2‐(2‐oxo‐2‐arylethyl)‐4 H ‐pyran‐4‐ones. They are formed as a result of multicomponent condensation of 5‐hydroxy‐2‐methyl‐4 H ‐pyran‐4‐one with arylglyoxals and 4‐methoxyaniline. Abstract :