A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature. (3rd November 2019)

• Record Type: Journal Article
• Authors: Thapa, Bicky; Ali, Asad; Nair, Raunak; Vashisht, Rishik; Calabrese, Cassandra
• Other Names: Koca Suleyman Serdar Academic Editor.
• Is Part Of: Case reports in rheumatology. Volume 2019(2019)
• Publication Date: 2019-11-03
• Subjects: Rheumatology -- Periodicals; Rheumatology -- Case studies -- Periodicals; Rheumatic Diseases; Connective Tissue Diseases; Rheumatology; Periodicals; Electronic journals; Case studies; Periodicals; 616.723
• DOI: 10.1155/2019/1326734
• Languages: English
• ISSNs: 2090-6889

Abstract

Abstract : Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, yet therapy is often hampered by immune-related adverse events (irAEs) which range from mild to severe life-threatening events. Musculoskeletal (MSK) irAEs leading to discontinuation of ICIs are uncommon but increasingly recognized. We report a challenging case of severe immune-related seronegative inflammatory arthritis due to nivolumab in a patient with stage IV metastatic adenocarcinoma.