Coexistence of Myeloid and Lymphoid Neoplasms: A Single-Center Experience. (3rd November 2019)

• Record Type: Journal Article
• Authors: Bouchla, Anthi; Thomopoulos, Thomas; Papageorgiou, Sotirios; Tsirigotis, Panagiotis; Bazani, Efthymia; Gkirkas, Konstantinos; Vasilatou, Diamantina; Glezou, Eirini; Stavroulaki, Georgia; Gkontopoulos, Konstantinos; Dimitriadis, George; Pappa, Vasiliki
• Other Names: Shiozawa Yusuke Academic Editor.
• Is Part Of: Advances in hematology. Volume 2019(2019)
• Publication Date: 2019-11-03
• Subjects: Hematology -- Periodicals; Hematologic Diseases; Hematology; Hematology; Periodicals; Periodicals; 616.15
• DOI: 10.1155/2019/1486476
• Languages: English
• ISSNs: 1687-9104

Abstract

Abstract : The coexistence of a myeloid and a lymphoid neoplasm in the same patient is a rare finding. We retrospectively searched the records of the Hematology Division of the Second Department of Internal Medicine and Research Institute at Attikon University General Hospital of Athens from 2003 to 2018. Nine cases have been identified in a total of 244 BCR-/ABL1- negative MPN and 25 MDS/MPN patients and 1062 LPD patients referred to our institution between 2003 and 2018. Each case is distinct in the diversity of myeloid and lymphoid entities, the chronological occurrence of the two neoplasms, and the patient clinical course. All of them exhibit myeloproliferative (6 JAK2 V617F -positive cases) and lymphoproliferative features, with 1 monoclonal B-cell lymphocytosis (MBL), 3 B-chronic lymphocytic leukemias (B-CLL), 3 B-non-Hodgkin lymphomas (B-NHL), 1 multiple myeloma (MM), and 1 light and heavy deposition disease (LHCDD), while in three cases myelodysplasia is also present. The challenges in identifying and dealing with these rare situations in everyday clinical practice are depicted in this article.