Fabrication of Mn2+-Doped Hollow Mesoporous Aluminosilica Nanoparticles for Magnetic Resonance Imaging and Drug Delivery for Therapy of Colorectal Cancer. (3rd November 2019)

• Record Type: Journal Article
• Authors: Lu, Yue; Zhao, Shirui; Zhang, Xin-an
• Other Names: Wang Ruibing Academic Editor.
• Is Part Of: Journal of nanomaterials. Volume 2019(2019)
• Publication Date: 2019-11-03
• Subjects: Nanostructured materials -- Periodicals; Nanotechnology -- Periodicals; Nanomatériaux; Nanostructured materials; Nanotechnology; Nanostructures; Nanotechnology; Periodicals; Fulltext; Internet Resources; Periodicals; 620.115
• DOI: 10.1155/2019/3525143
• Languages: English
• ISSNs: 1687-4110

Abstract

Abstract : A novel Mn 2+ -doped hollow Mn-HMAS aluminosilica (Mn-HMAS) nanoparticle for simultaneous T 1 -weighted magnetic resonance imaging and drug delivery was reported. The magnetic resonance tests showed that the Mn-HMAS nanoparticles display an excellent T 1 -weighted magnetic resonance imaging effect with a high T 1 relaxivity (r1) of 8.8 mM -1 S -1 . The MTT assays showed that the Mn-HMAS-DOX nanoparticles possess a better tumour cell inhibition effect than DOX. In addition, the Mn-HMAS nanoparticles also exhibit good stability and noncytotoxicity. These results demonstrated that the Mn-HMAS nanoparticles can be applied for the loading and delivery of various drugs in medicine.