The application of near-infrared spectroscopy in oxygen therapy for premature infants. (17th January 2020)

• Record Type: Journal Article
• Authors: Yang, Xi; Lei, Xiaoping; Zhang, Lianyu; Zhang, Lingping; Dong, Wenbin
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 33:Number 2(2020)
• Page Start: 283
• Page End: 288
• Publication Date: 2020-01-17
• Subjects: Blood gas analysis -- near-infrared spectroscopy -- premature infants -- pulmonary regional oxygen saturation; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2018.1489535
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective: This study used near-infrared spectroscopy (NIRS) to detect the pulmonary regional oxygen saturation (rSO2 ) of premature infants. The oxygenation state of the lung tissue was also evaluated, which provided preliminary evidence regarding the application of NIRS in oxygen therapy for premature infants. Methods: NIRS was used to measure the pulmonary rSO2 of 26 premature infants (gestational age <32 weeks). The correlations between pulmonary rSO2 and the arterial partial pressure of oxygen (PaO2 ), arterial oxygen saturation (SaO2 ), and pulse oxygen saturation (SpO2 ) were analyzed. The diagnostic value of NIRS was evaluated via both Pearson's correlation and receiver operating characteristic (ROC) curve analyses. Results: Pulmonary rSO2 was positively correlated with both PO2 and SaO2 ; the linear correlation coefficients ( r ) were 0.544 ( p = .004) and 0.515 ( p = .007), respectively. No significant correlation was found between rSO2 and SpO2 ( p = .098). SpO2 was positively correlated with PO2 ( r = 0.402, p = .042) and SaO2 ( r = 0.625, p = .001). NIRS could be used to predict hypoxemia (area under the curve [AUC] = 0.843; Youden's index =0.654) when the pulmonary rSO2 was 62.39%, the sensitivity was 88.9%, and the specificity was 23.5% ( p = .005) as well as predict hyperoxemia (AUC = 0.775; Youden's index = 0.65) when the pulmonary rSO2 was 61.99%, the sensitivity was 100%, and the specificity was 35% ( p = .045). SpO2 predicted hypoxemia (AUC = 0.784, p = .019) but not hyperoxemia (AUC = 0.7, p = .144). Conclusion: NIRS objectively reflects the changes in oxygenation in the lung tissue. This study provides evidence for the clinical application of NIRS.