Linear PVA–DTPA–Gd conjugate for magnetic resonance imaging. Issue 63 (12th November 2019)

• Record Type: Journal Article
• Authors: Xu, Weibing; Lin, Zhiyan; Li, Guichen; Long, Haitao; Du, Mingyuan; Fu, Guorui; Pu, Lumei
• Is Part Of: RSC advances. Volume 9:Issue 63(2019)
• Page Start: 37052
• Page End: 37056
• Publication Date: 2019-11-12
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra05607f
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : In this study, we report the preparation and characterization of the PVA–DTPA–Gd conjugate as a potential MRI contrast agent (CA). Abstract : In this study, we report the preparation and characterization of the PVA–DTPA–Gd conjugate as a potential MRI contrast agent (CA). The r 1 value and the r 2 / r 1 ratio were about 5.6 mM −1 s −1 and 1.31, respectively. In vitro toxicity studies not only demonstrated that the polymeric system possessed good biocompatibility, but also proved that the conjugate could be an attractive candidate for CA.