Rhodium-catalyzed biheteroaryl-2-carbonitrile synthesis via double C–H activation. Issue 23 (22nd October 2019)

• Record Type: Journal Article
• Authors: Xu, Hui-Bei; Zhu, Yan-Ying; Yang, Jia-Hui; Chai, Xin-Yue; Dong, Lin
• Is Part Of: Organic chemistry frontiers. Volume 6:Issue 23(2019)
• Page Start: 3864
• Page End: 3867
• Publication Date: 2019-10-22
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c9qo01114e
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Rhodium(iii )-catalyzed double C–H activation and in situ dealcoholization to generate biheteroaryl-2-carbonitriles have been developed via a CDC mechanism, in which benzimidates act as both directing groups and the precursors of nitrile groups. Abstract : Rhodium(iii )-catalyzed double C–H activation and in situ dealcoholization to generate useful biheteroaryl-2-carbonitriles have been well developed via a CDC mechanism, in which benzimidates act as both directing groups and the precursors of nitrile groups. This simple and atom-economical method synthesizes various biheteroaryl-2-carbonitrile derivatives, which could be further transformed to more complex compounds.