Visible-light-mediated de-aminative alkylation of N-arylamines with alkyl Katritzky salts. Issue 23 (29th October 2019)

• Record Type: Journal Article
• Authors: Xu, Yuliang; Xu, Ze-Jun; Liu, Zhao-Peng; Lou, Hongxiang
• Is Part Of: Organic chemistry frontiers. Volume 6:Issue 23(2019)
• Page Start: 3902
• Page End: 3905
• Publication Date: 2019-10-29
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c9qo01175g
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A visible-light-mediated de-aminative alkylation of N -arylamines has been developed, providing direct access to α-amino C–H functionalization from readily available Katritzky salts under mild conditions. Abstract : A visible-light-mediated de-aminative alkylation of N -arylamines has been developed, providing direct access to α-amino C–H functionalization from readily available Katritzky salts under mild conditions. In some cases, this operationally simple protocol can be performed in the absence of a photocatalyst. A wide range of substrates and functional groups are tolerated. The utility of this approach is highlighted by its application to the late-state modification of drug molecules, natural products and peptides.