Incorporation of 7-dehydrocholesterol into liposomes as a simple, universal and efficient way to enhance anticancer activity by combining PDT and photoactivated chemotherapy. Issue 93 (7th November 2019)

• Record Type: Journal Article
• Authors: Wang, Youchao; Tian, Nana; Li, Chao; Hou, Yuanjun; Wang, Xuesong; Zhou, Qianxiong
• Is Part Of: Chemical communications. Volume 55:Issue 93(2019)
• Page Start: 14081
• Page End: 14084
• Publication Date: 2019-11-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc05691b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Incorporation of 7-dehydrocholesterol instead of cholesterol can efficiently enhance the anticancer activity of photosensitizer-encapsulated liposomes upon irradiation. Abstract : Cholesterol (CHOL) is an indispensable component of liposomes. Incorporation of 7-dehydrocholesterol (7-DHC) instead of CHOL can efficiently enhance the anticancer activity of photosensitizer-encapsulated liposomes upon irradiation, yielding an IC50 value about half of that of CHOL-based controls. The photo-oxidation of 7-DHC into its endoperoxide form by singlet oxygen may account for the enhanced therapeutic effect, realizing an efficient combination of photodynamic therapy (PDT) and photoactivated chemotherapy.