Hypertonic Saline Infusion Acutely Degrades Mood in Healthy Volunteers (P23-014-19). (13th June 2019)
- Record Type:
- Journal Article
- Title:
- Hypertonic Saline Infusion Acutely Degrades Mood in Healthy Volunteers (P23-014-19). (13th June 2019)
- Main Title:
- Hypertonic Saline Infusion Acutely Degrades Mood in Healthy Volunteers (P23-014-19)
- Authors:
- Suh, HyunGyu
Lieberman, Harris
Jansen, Lisa
Adams, J D
Seal, Adam
Butts, Cory
Colburn, Abigail
Kirkland, Tracie
Sprong, Cameron
Melander, Olle
Lemetais, Guillaume
Vanhaecke, Tiphaine
Dolci, Alberto
Perrier, Erica
Kavouras, Stavros - Abstract:
- Abstract: Objectives: Mild and moderate dehydration adversely affect mood and cognitive function. During dehydration, hypertonic hypovolemia activates both osmo- and baro-receptors but it is not known which physiological pathway is associated with degraded mood state. This study examined the acute effect of osmoreceptor stimulation on mood. Methods: Sixty healthy adults (50% females, 30 ± 1 y; BMI: 26.9 ± 4.0 kg·m −2 ) were infused intravenously with 3.0% (HYPER) or 0.9% (ISO) NaCl for 2 h (0.1 ml·kg −1 ·min −1 ) using a counterbalanced, crossover design. Blood samples were collected every 30 minutes to measure plasma osmolality (POsm), copeptin (a surrogate marker of vasopressin), and renin-angiotensin-aldosterone system (RAAS) hormones. Mood was assessed with the short version of Profile of Mood State (POMS) questionnaire before and after the infusion. Results: POsm and copeptin increased from 286 ± 3 mmol·kg −1 to 305 ± 4 mmol·kg −1 and from 4.5 ± 3.7 pmol·L −1 to 20.4 ± 12.8 pmol·L −1, respectively in HYPER ( P < 0.05), and were unchanged in ISO ( P > 0.05). No hormonal differences were observed between trials for RAAS hormones ( P > 0.05). During HYPER copeptin, following the 2-h infusion, was greater in females than in males (female: 23.4 ± 13.9 pmol·L −1, male: 17.4 ± 10.9 pmol·L −1 ; P < 0.05). The POMS total mood disturbance (TMD) score increased from 10.5 ± 0.9 to 16.5 ± 1.6 in HYPER ( P < 0.05), but not in ISO ( P > 0.05). Among POMS subscales,Abstract: Objectives: Mild and moderate dehydration adversely affect mood and cognitive function. During dehydration, hypertonic hypovolemia activates both osmo- and baro-receptors but it is not known which physiological pathway is associated with degraded mood state. This study examined the acute effect of osmoreceptor stimulation on mood. Methods: Sixty healthy adults (50% females, 30 ± 1 y; BMI: 26.9 ± 4.0 kg·m −2 ) were infused intravenously with 3.0% (HYPER) or 0.9% (ISO) NaCl for 2 h (0.1 ml·kg −1 ·min −1 ) using a counterbalanced, crossover design. Blood samples were collected every 30 minutes to measure plasma osmolality (POsm), copeptin (a surrogate marker of vasopressin), and renin-angiotensin-aldosterone system (RAAS) hormones. Mood was assessed with the short version of Profile of Mood State (POMS) questionnaire before and after the infusion. Results: POsm and copeptin increased from 286 ± 3 mmol·kg −1 to 305 ± 4 mmol·kg −1 and from 4.5 ± 3.7 pmol·L −1 to 20.4 ± 12.8 pmol·L −1, respectively in HYPER ( P < 0.05), and were unchanged in ISO ( P > 0.05). No hormonal differences were observed between trials for RAAS hormones ( P > 0.05). During HYPER copeptin, following the 2-h infusion, was greater in females than in males (female: 23.4 ± 13.9 pmol·L −1, male: 17.4 ± 10.9 pmol·L −1 ; P < 0.05). The POMS total mood disturbance (TMD) score increased from 10.5 ± 0.9 to 16.5 ± 1.6 in HYPER ( P < 0.05), but not in ISO ( P > 0.05). Among POMS subscales, depression-dejection and fatigue-inertia increased in HYPER compared to ISO ( P < 0.05). When TMD responses in the HYPER trial were analyzed with sex as a between-subjects factor, the increase was significant in females (pre: 10.2 ± 1.0, post: 18.6 ± 2.3; P < 0.001) but not in males (pre: 10.8 ± 1.4, post: 14.0 ± 2.0; P > 0.05). The confusion-bewilderment subscales and fatigue-inertia of the POMS were also elevated post HYPER in females ( P < 0.05), but not in ISO ( P > 0.05) in either sex. Conclusions: Hypertonic saline infusion acutely degrades mood state, and women appear to have a more pronounced response. The underlying mechanisms remain to be determined but may be related to higher copeptin levels in women. The study was registered at ClinicalTrials.gov as NCT02761434. Funding Sources: Danone Research. Supporting Tables, Images and/or Graphs: … (more)
- Is Part Of:
- Current developments in nutrition. Volume 3(2019)Supplement 1
- Journal:
- Current developments in nutrition
- Issue:
- Volume 3(2019)Supplement 1
- Issue Display:
- Volume 3, Issue 1 (2019)
- Year:
- 2019
- Volume:
- 3
- Issue:
- 1
- Issue Sort Value:
- 2019-0003-0001-0000
- Page Start:
- Page End:
- Publication Date:
- 2019-06-13
- Subjects:
- Nutrition -- Periodicals
Nutritional Physiological Phenomena
Nutrition
Periodicals
Periodicals
Fulltext
Internet Resources
Periodicals
612.3 - Journal URLs:
- https://academic.oup.com/cdn ↗
https://www.sciencedirect.com/journal/current-developments-in-nutrition ↗
https://cdn.nutrition.org/ ↗
http://www.oxfordjournals.org/ ↗ - DOI:
- 10.1093/cdn/nzz043.P23-014-19 ↗
- Languages:
- English
- ISSNs:
- 2475-2991
- Deposit Type:
- Legaldeposit
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