Effects of Chronic L-theanine on Stress-related Symptoms and Cognitive Function in a Non-clinical Population: A Randomized Controlled Trial (P06-106-19). (13th June 2019)

• Record Type: Journal Article
• Authors: Kunugi, Hiroshi; Hidese, Shinsuke; Ogawa, Shintaro; Ota, Miho; Yasukawa, Zenta; Ozeki, Makoto
• Is Part Of: Current developments in nutrition. Volume 3(2019)Supplement 1
• Publication Date: 2019-06-13
• Subjects: Nutrition -- Periodicals; Nutritional Physiological Phenomena; Nutrition; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 612.3
• DOI: 10.1093/cdn/nzz031.P06-106-19
• Languages: English
• ISSNs: 2475-2991

Abstract

Abstract: Objectives: This randomized, placebo-controlled, and double-blind, crossover study aimed to investigate the effects of chronic L-theanine (Suntheanine®) administration on stress-related symptoms and cognitive functions in a non-clinical population. Methods: Participants were 9 men and 21 women (mean age: 48.3 ± 11.9 years) who had no psychiatric illness of clinical level. L-theanine (200 mg/day) or placebo tablets were randomly assigned to participants for 4 weeks administration. After 2 weeks of wash-out period, the crossover study was continued for 4 weeks. Stress related symptoms were assessed using Self-rating Depression Scale (SDS), State-Trait Anxiety Inventory (STAI), and Pittsburgh Sleep Quality Index (PSQI). Cognitive functions were assessed with Brief Assessment of Cognition in Schizophrenia (BACS). Results: SDS, STAI-trait, and PSQI scores significantly decreased after 4 weeks of L-theanine administration, while there were no significant changes after placebo. Verbal fluency and executive function scores of BACS significantly increased (p = 0.001 and 0.031) after L-theanine, but not placebo, administration. Changes in sleep latency, sleep disturbance, and use of sleep medication subscales of PSQI were significantly better in the L-theanine than in the placebo group. Changes in SDS and PSQI total scores also tended to be better in L-theanine than in placebo group. The rate of individuals who showed an improvement in BACS executive function score (5 or more) was significantly greater in L-theanine group than in placebo group. There was no significant adverse event after chronic L-theanine administration. Conclusions: The results suggest that 4 weeks of L-theanine (200 mg/day) administration is safe and effective on stress-related symptoms and cognitive functions in a non-clinical population. Funding Sources: This research was funded by Taiyo Kagaku, Co. Ltd.