Association of Habitual Coffee Consumption and HECTD4 Polymorphism with Risk of Prediabetes and Type 2 Diabetes (P18-071-19). (13th June 2019)

• Record Type: Journal Article
• Authors: Jin, Taiyue; Youn, Jiyoung; Kang, Moonil; Sung, Joohon; Lee, Jung Eun; Kim, An Na
• Is Part Of: Current developments in nutrition. Volume 3(2019)Supplement 1
• Publication Date: 2019-06-13
• Subjects: Nutrition -- Periodicals; Nutritional Physiological Phenomena; Nutrition; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 612.3
• DOI: 10.1093/cdn/nzz039.P18-071-19
• Languages: English
• ISSNs: 2475-2991

Abstract

Abstract: Objectives: Epidemiological studies suggested the evidence that coffee consumption decreased risk of type 2 diabetes. Recently, Japanese genome-wide association studies (GWAS) of coffee consumption has identified rs2074356 (G > A) at 12q24.12–13 in HECTD4 . This study aims to examine the associations of habitual coffee consumption with prediabetes and type 2 diabetes, and whether this association is modified by rs2074356 variant in Korean adults. Methods: A total of 4010 participants (1890 men and 2120 women) who had genetic information from Korea Association REsource (KARE) study were included. Habitual coffee consumption was assessed through a food frequency questionnaire and categorized into five categories (non-consumers, <1 cup/day and ≥1 cups/day of black coffee, and <1 cup/day and ≥1 cups/day of sugared coffee). Incident prediabetes or type 2 diabetes were defined according to the self-report of physician-diagnosis, oral glucose tolerance test (OGTT) or hemoglobin A1c (HbA1c) test. Multivariable logistic regression models were used to calculate odds ratio (OR)s and 95% confidence interval (CI)s. Results: A total of 2916 participants (72.7%) have developed prediabetes during a follow-up of 15 years. We found that black coffee consumption lowered risk of prediabetes and type 2 diabetes combined among men and women combined (OR = 0.63; 95% CI = 0.44–0.91 for ≥1 cups/day black coffee vs. non-consumers). When we separated men and women, compared with non-consumers, ORs (95% CIs) for ≥1 cups/day of black coffee were 0.50 (0.27–0.93) among men and 0.72 (0.45–1.14) among women and ORs (95% CIs) for ≥1 cups/day of sugared coffee were 1.41 (0.91–2.18) among men and 1.12 (0.80–1.58) among women. We observed a suggestive difference by rs2074356 (GG vs. AG + AA). Compared with non-consumers, participants with AG + AA genotypes consumed ≥ 1 cups/day of black coffee had a 60% lower risk of prediabetes and type 2 diabetes combined (95% CI 0.20–0.78), but we found a weaker association among those with GG genotype (OR = 0.81; 95% CI = 0.51–1.28). Conclusions: We observed an inverse association between black coffee consumption and prediabetes and type 2 diabetes combined in Korean population. This association was more pronounced among carriers of minor allele of HECTD4 rs2074356 (AG/AA). Funding Sources: None.