Gut Microbial-Related Choline Metabolite Trimethylamine-N-Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection. (15th June 2018)

• Record Type: Journal Article
• Authors: Shan, Zhilei; Clish, Clary B; Hua, Simin; Scott, Justin M; Hanna, David B; Burk, Robert D; Haberlen, Sabina A; Shah, Sanjiv J; Margolick, Joseph B; Sears, Cynthia L; Post, Wendy S; Landay, Alan L; Lazar, Jason M; Hodis, Howard N; Anastos, Kathryn; Kaplan, Robert C; Qi, Qibin
• Is Part Of: Journal of infectious diseases. Volume 218:Number 9(2018)
• Page Start: 1474
• Page End: 1479
• Publication Date: 2018-06-15
• Subjects: trimethylamine-N-oxide -- choline metabolites -- carotid atherosclerosis -- HIV infection -- risk factors; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiy356
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident plaque cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine- N -oxide (TMAO) was associated with an increased risk of carotid plaque in HIV-infected participants (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05–1.50; P = .01). TMAO was positively correlated with biomarkers of monocyte activation and inflammation (sCD14, sCD163). Further adjustment for these biomarkers attenuated the association between TMAO and carotid plaque ( P = .08). Among HIV-infected individuals, plasma TMAO was associated with carotid atherosclerosis progression, partially through immune activation and inflammation. Abstract : Higher plasma TMAO, a gut microbial-related choline metabolite, was associated with greater progression of carotid artery atherosclerosis in HIV-infected individuals, suggesting a potential role of gut microbiota and related TMAO in the development of cardiovascular disease in HIV-infected individuals.