Management of chronic hepatitis B during pregnancy. (24th July 2018)

• Record Type: Journal Article
• Authors: Aslam, Aysha; Campoverde Reyes, Karen Joanie; Malladi, Vijayram Reddy; Ishtiaq, Rizwan; Lau, Daryl T Y
• Is Part Of: Gastroenterology report. Volume 6:Number 4(2018:Nov.)
• Page Start: 257
• Page End: 262
• Publication Date: 2018-07-24
• Subjects: Chronic hepatitis B -- pregnancy -- nucleoside analogue -- hepatitis B therapy; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1093/gastro/goy025
• Languages: English
• ISSNs: 2052-0034

Abstract

Abstract: Chronic hepatitis B is globally prevalent and is a major cause of cirrhosis and hepatocellular carcinoma. Despite immunoprophylaxis against hepatitis B in pregnancy, perinatal transmission still occurs in at least 10% of the children born to a mother with high level of viremia. Decisions regarding hepatitis B therapy during pregnancy must take into account the benefits and safety for both the mother and the unborn baby. In this review, we summarize the current treatment options for chronic hepatitis B with a focus on management during pregnancy and the evidence-based strategies to prevent vertical transmission of hepatitis B virus (HBV).