F73. EEG COHERENCE ABNORMALITIES IN PATIENTS WITH SCHIZOPHRENIA AND THEIR UNAFFECTED SIBLINGS. (9th April 2019)

• Record Type: Journal Article
• Authors: Lee, Yu Sang; Han, Changwoo
• Is Part Of: Schizophrenia bulletin. Volume 45(2019)Supplement 2
• Page Start: S282
• Page End: S282
• Publication Date: 2019-04-09
• Subjects: Schizophrenia -- Periodicals; Schizophrenia -- Research -- Periodicals; 616.898005
• DOI: 10.1093/schbul/sbz018.485
• Languages: English
• ISSNs: 0586-7614

Abstract

Abstract: Background: The dysconnectivity of brain circuit is considered as a core feature of schizophrenia. EEG coherence is known to reflect the connectivity in brain circuit. To investigate EEG coherence as a potential trait marker for schizophrenia, we examined the differences of EEG coherence among patients with schizophrenia, their healthy siblings and controls. Methods: Fifteen patients with schizophrenia were recruited from one psychiatric hospital in Korea. Sixteen individuals of patient's unaffected siblings and 18 healthy controls were recruited. Resting-state eyes-closed electroencephalography (EEG) was recorded in 19 channels. EEG coherence was calculated. The statistical differences of EEG coherence among patients with schizophrenia, unaffected siblings and healthy controls were examined using ANOVA. Results: EEG coherence was increased in patients with schizophrenia compared with healthy controls in beta frequency bands of F8O2, F3T5 and F4T6. EEG coherence of unaffected sibling group was not statistically different from healthy control group in beta frequency bands but was shown in the middle range between patients with schizophrenia and healthy controls. In delta frequency bands of C3C4 and T5T6, EEG coherence of sibling group was significantly increased compared with those of healthy controls. Discussion: These findings suggest that EEG coherence could be a trait marker for schizophrenia. Further studies need to be done with larger samples. In addition, gene mapping of EEG coherence may help to elucidate pathogenesis of schizophrenia.