Cancer immunotherapy for metastasis: past, present and future. (9th July 2018)

• Record Type: Journal Article
• Authors: Wang, Xiaobo; Fan, Shaoyi; Pan, Hehai; Chen, Wenli; Wang, Hua
• Is Part Of: Briefings in functional genomics. Volume 18:Number 2(2019)
• Page Start: 140
• Page End: 146
• Publication Date: 2018-07-09
• Subjects: cancer immunotherapy -- gene -- vaccines -- immune checkpoint blockade -- adoptive cell transfer (ACT); Genomics -- Methodology -- Periodicals; Genomics -- Technological innovations -- Periodicals; 572.86072
• DOI: 10.1093/bfgp/ely022
• Languages: English
• ISSNs: 2041-2649

Abstract

Abstract: Cancer is a complex and refractory disease, which can disseminate from primary site to a different site even at an early stage. Cancer immunotherapy harnesses host immune system to battle against cancer, but only a minority of patients benefit from it. Genetic-based technologies have significantly promoted the development of cancer immunotherapy. Here we describe genetic-based cancer immunotherapies in three aspects: recombinant cancer vaccine, immune checkpoint blockade therapy and adoptive cell transfer. In the future, multi-disciplinary collaboration will greatly increase the scope and effectiveness of cancer immunotherpy.