3D echocardiographic reference ranges for normal left ventricular volumes and strain: results from the EACVI NORRE study. (22nd December 2016)

• Record Type: Journal Article
• Authors: Bernard, Anne; Addetia, Karima; Dulgheru, Raluca; Caballero, Luis; Sugimoto, Tadafumi; Akhaladze, Natela; Athanassopoulos, George D.; Barone, Daniele; Baroni, Monica; Cardim, Nuno; Hagendorff, Andreas; Hristova, Krasimira; Ilardi, Federica; Lopez, Teresa; de la Morena, Gonzalo; Popescu, Bogdan A.; Penicka, Martin; Ozyigit, Tolga; David Rodrigo Carbonero, Jose; van de Veire, Nico; Stephan Von Bardeleben, Ralph; Vinereanu, Dragos; Luis Zamorano, Jose; Martinez, Christophe; Magne, Julien; Cosyns, Bernard; Donal, Erwan; Habib, Gilbert; Badano, Luigi P.; Lang, Roberto M.; Lancellotti, Patrizio;
• Is Part Of: European heart journal. Volume 18:Number 4(2017:Apr.)
• Page Start: 475
• Page End: 483
• Publication Date: 2016-12-22
• Subjects: adult echocardiography -- three-dimensional echocardiography -- left ventricular function -- deformation imaging -- reference values; Cardiovascular system -- Imaging -- Periodicals; Heart -- Imaging -- Periodicals; 616.10754
• DOI: 10.1093/ehjci/jew284
• Languages: English
• ISSNs: 2047-2404

Abstract

Abstract : Aim: To obtain the normal ranges for 3D echocardiography (3DE) measurement of left ventricular (LV) volumes, function, and strain from a large group of healthy volunteers. Methods and results: A total of 440 (mean age: 45 ± 13 years) out of the 734 healthy subjects enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study had good-quality 3DE data sets that have been analysed with a vendor-independent software package allowing homogeneous measurements regardless of the echocardiographic machine used to acquire the data sets. Upper limits of LV end-diastolic and end-systolic volumes were larger in men (97 and 42 mL/m 2 ) than in women (82 and 35 mL/m 2 ; P < 0.0001). Conversely, lower limits of LV ejection fraction were higher in women than in men (51% vs. 50%; P < 0.01). Similarly, all strain components were higher in women than in men. Lower range was −18.6% in men and −19.5% in women for 3D longitudinal strain, −27.0% and −27.6% for 3D circumferential strain, −33.2% and −34.4% for 3D tangential strain and 38.8% and 40.7% for 3D radial strain, respectively. LV volumes decreased with age in both genders ( P < 0.0001), whereas LV ejection fraction increased with age only in men. Among 3DE LV strain components, the only one, which did not change with age was longitudinal strain. Conclusion: The NORRE study provides applicable 3D echocardiographic reference ranges for LV function assessment. Our data highlight the importance of age- and gender-specific reference values for both LV volumes and strain.