Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons. (7th June 2017)

• Record Type: Journal Article
• Authors: Sparks, Rachel; Koelle, David M.; Stern, Joshua E.; Dhanireddy, Shireesha
• Is Part Of: Open forum infectious diseases. Volume 4:Number 2(2017)
• Publication Date: 2017-06-07
• Subjects: HIV -- immune activation -- interferon-γ -- interferon-γ release assay -- tuberculosis.; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofx055
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Immune activation in human immunodeficiency virus (HIV) is a well described phenomenon. We found that HIV patients have higher secretion of interferon (IFN)-γ compared with non-HIV subjects, as measured by the "nil" value in the QuantiFERON-TB Gold test, even when viral loads are low. This may reflect ongoing immune activation, even with optimal HIV management.