Euler–Lagrange approach to investigate respiratory anatomical shape effects on aerosol particle transport and deposition. (12th December 2019)

• Record Type: Journal Article
• Authors: Islam, Mohammad S; Saha, Suvash C; Sauret, Emilie; Ong, Hui; Young, Paul; Gu, YT
• Is Part Of: Toxicology research and application. Volume 3(2019)
• Publication Date: 2019-12-12
• Subjects: Deposition hot spot -- particle shape -- anatomical shape -- drug delivery -- pharmaceutical aerosol; Toxicology -- Periodicals; 571.9505
• DOI: 10.1177/2397847319894675
• Languages: English
• ISSNs: 2397-8473

Abstract

An accurate knowledge of the pulmonary aerosol particle transport in the realistic lung is essential to deliver the therapeutic particle to the targeted site of the bifurcating airways. The available in silico studies have enriched the knowledge of the aerosol transport and deposition (TD) in the lung; however, the absolute TD data in the realistic lung airway are still elusive. Therefore, in this study, a 3-D geometry of the human lung central airway is developed from the computed tomography (CT) images. A CT scan-based modified lung geometry with a smooth surface and nonrealistic Weibel's lung geometry is also generated. The coal mine exhausted aerosol TD in the upper airway is investigated. The Euler–Lagrange (E-L) method for particle tracking and ANSYS Fluent solver are used to carry out the entire investigation. The effective diameter method is employed to define the shape-specific particles and is integrated with the E-L method. The anatomical shape effects on the deposition patterns are investigated for different deposition parameter. The numerical results illustrated that the airway geometry, particle shape, particle diameter, and breathing flow rates significantly influence the aerosol TD pattern in the upper airway. The present study reports that airway tracheal wall is the new deposition hot spot for the CT-based geometry instead of bifurcating area for the idealized model, which might be helpful for zone-specific drug delivery to the respiratory airways.