Tyrosine-hydroxylase, dopamine β-hydroxylase and choline acetyltransferase-like immunoreactive fibres in the human major sublingual gland. (January 2020)

• Record Type: Journal Article
• Authors: Loy, Francesco; Serra, Maria Pina; Boi, Marianna; Isola, Raffaella; Ekström, Jörgen; Quartu, Marina
• Is Part Of: Archives of oral biology. Volume 109(2020)
• Publication Date: 2020-01
• Subjects: PBS phosphate-buffered saline -- ABC avidin–biotin–peroxidase complex -- TH tyrosine hydroxylase -- ChAT choline acetyltransferase -- DBH dopamine-β-hydroxylase; Human major sublingual gland -- Tyrosine hydroxylase -- Dopamine beta-hydroxylase -- Choline acetyltransferase -- Immunohistochemistry; Mouth -- Periodicals; Mouth -- Diseases -- Periodicals; Dentistry -- Periodicals; Electronic journals; 617.6005
• DOI: 10.1016/j.archoralbio.2019.104571
• Languages: English
• ISSNs: 0003-9969

Abstract

Highlights: Sympathetic and parasympathetic fibers supply the human major sublingual gland. TH- and DBH-immunostained fibers and terminals reach sublingual acini and ducts. The major sublingual gland likely adds to the sympathetic-induced mucin secretion. Abstract: Objective: To study the innervation of the major sublingual gland by means of immunohistochemistry. Design: Bioptic and autoptic specimens of the major sublingual gland of humans were examined for the presence of immunoreactivity to tyrosine hydroxylase and dopamine-β-hydroxylase, on one hand, and choline acetyltransferase, on the other, to indicate adrenergic and cholinergic nerves, respectively. Results: Acini and ducts were supplied by both divisions of the autonomic nervous system. Conclusions: Mucous and seromucous cells of the human major sublingual glands may respond with secretion not only to parasympathetic activity but also to sympathetic activity. The major sublingual gland is therefore a potential contributor to the mucin secretion recently reported in the literature in response to high sympathetic activity during physical exercise.