Managing Infants Exposed to Maternal Chorioamnionitis by the Use of Early-Onset Sepsis Calculator. (April 2019)

• Record Type: Journal Article
• Authors: Sharma, Vinay; Adkisson, Constance; Gupta, Kunal
• Is Part Of: Global pediatric health. Volume 6(2019)
• Publication Date: 2019-04
• Subjects: Maternal Chorioamnionitis -- Early onset sepsis -- Neonatal sepsis; Pediatrics -- Periodicals; Children -- Health and hygiene -- Periodicals; 618.92
• DOI: 10.1177/2333794X19833711
• Languages: English
• ISSNs: 2333-794X

Abstract

Objective . To reduce neonatal intensive care unit admission rate (NAR) and antibiotic utilization rate (AUR) in ≥36 weeks gestational age infants exposed to maternal chorioamnionitis (MC) through the application of early-onset sepsis calculator (EOSCAL). Study Design . This is a single-center cohort study. All infants born ≥36 weeks gestational age and exposed to MC were compared for NAR, AUR, and laboratory evaluation rate (LER) 2 years after and 1 year before the implementation of EOSCAL. Results . There is a significant decrease in NAR ( P < .001), AUR ( P < .04), and LER for blood culture, complete blood count, and C-reactive protein ( P < .001) after implementation of EOSCAL. If infants received antibiotics, it was for significantly less number of doses ( P < .01). There was no increase in the readmission rate. Conclusion . Use of EOSCAL significantly decreases the rate of NAR, AUR, and LER in infants exposed to MC, without affecting readmission rates and late antibiotic use.