N‐Arylation of Fluoroalkylamine and Trifluoroacetamide through Cu–Catalysis. Issue 41 (5th November 2019)

• Record Type: Journal Article
• Authors: Xin, Jiaqi; Leng, Faqiang
• Is Part Of: ChemistrySelect. Volume 4:Issue 41(2019)
• Page Start: 12124
• Page End: 12127
• Publication Date: 2019-11-05
• Subjects: copper -- catalysis -- N-arylation -- trifluoroethylamine -- trifluoroacetamide; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201902689
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Copper mediated coupling of fluoro‐alkylamines/trifluoroacetamide and aryl‐boronic acids have been developed. N‐arylation of di/trifluoroethylamine was achieved by a Cu(OAc)2 /Py system with AgNO3 as an additive, while the N‐arylation of trifluoroacetamide was described with Cu(OAc)2 /TEA system. These protocols could tolerate a variety of functional groups of hetero/aryl‐boronic acids, furnishing the corresponding products with moderate to good yields under mild and simple conditions. Abstract : Two simple and effective protocols to prepare N‐(fluoroalkyl/fluoroacetamide) aniline were developed. Various functional groups of aryl‐boronic acid were well tolerated. The selective of N‐arylation of fluoroalkylamine and fluoroacetamide was dramatically affected by the base.