DOZ047.39: Respiratory morbidity at the age of one year in children with esophageal atresia: data from the French National Esophageal Atresia Register. (24th June 2019)

• Record Type: Journal Article
• Authors: Lejeune, S; Rousseau, V; Bonnard, A; Michaud, L; Gelas, T; Boubnova, J; Jacquier, C; Irtan, S; Breton, A; Fouquet, V; Guinot, A; Lamireau, T; Habonimana, E; Schneider, A; Elbaz, F; Ranke, A; Poli-Merol, M L; Allal, H; Petit, T; Michel, J-L; Buisson, P; Sapin, Z; Lardy, H; Levard, G; Lopez, M; Schmitt, F; Borderon, C; Jaby, O; Pelatan, C; De Vries, P; Pouzac-Arnould, M; Grosos, C; Breaud, J; Tolg, C; Auber, F; Geiss, S; Laplace, C; Sfeir, R; Gottrand, F; Drumez, E; Mourad, S El; Thumerelle, C;
• Is Part Of: Diseases of the esophagus. Volume 32(2019)Supplement 1
• Publication Date: 2019-06-24
• Subjects: esophageal atresia -- hospitalization -- respiratory morbidity; Esophagus -- Diseases -- Periodicals; 616.32
• DOI: 10.1093/dote/doz047.39
• Languages: English
• ISSNs: 1120-8694

Abstract

Abstract : Summary: Respiratory diseases are common in children with esophageal atresia (EA), leading to an increased morbidity and mortality in the first months of life. Objective: Assess the prevalence of hospitalizations linked to a respiratory disease and of maintenance inhaled therapy at the age of 1 year in French children. Methods: Population based-study using data from the French national EA register. We included all children born between 2010 and 2015 with data available at birth and at follow-up at one year of age. Results: A total of 981 patients born with EA were included in the register, 75 of them (8%) being deceased at the age of 1 year. Data were missing for 60 patients, thus 846 children (86%) were retained for analysis. EAs were type III of Ladd classification in 89% and type I in 7%. Rate of prematurity was 37% while 51% presented associated malformations. At 1 year of age, 1297 hospitalizations were reported for 508 patients (60%), at least one hospitalization for a respiratory disease for 251 children (51%). Factors significantly associated with respiratory hospitalizations were longer median length of oxygen supplementation ( P < 10 −2 ) and noninvasive ventilation in the neonatal period ( P = 0.02), gastrostomy tube ( P < 10 −2 ), esophageal anastomosis dilation ( P < 10 −2 ). At 1 year of age, 29% had an inhaled maintenance treatment, and 85% inhaled corticosteroids. Factors significantly associated with inhaled maintenance treatment were male gender ( P = 0.04), advanced older median age at gastrostomy tube insertion ( P < 10 −3 ), enteral feeding at one year of age ( P < 10 −3 ). Conclusion: This study shows a high rate of respiratory problems responsive of frequent hospitalizations and inhaled maintenance treatment in children born with EA in the first year of life.