Surface‐enhanced Raman scattering‐active photonic crystal fiber probe: Towards next generation liquid biopsy sensor with ultra high sensitivity. Issue 11 (21st May 2019)

• Record Type: Journal Article
• Authors: Dinish, U. S; Beffara, Flavien; Humbert, Georges; Auguste, Jean‐Louis; Olivo, Malini
• Is Part Of: Journal of biophotonics. Volume 12:Issue 11(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-05-21
• Subjects: biosensor -- liquid biopsy -- photonic crystal fiber -- Raman spectroscopy -- surface‐enhanced Raman spectroscopy; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201900027
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract: The tremendous enhancement factors that surface‐enhanced Raman scattering (SERS) possesses coupled with the flexibility of photonic crystal fibers (PCFs) pave the way to a new generation of ultrasensitive biosensors. Thanks to the unique structure of PCFs, which allows direct incorporation of an analyte into the axially aligned air channels, interaction between the analyte and excitation light could be increased many folds leading to flexible, reliable and sensitive probes that can be used in preclinical or clinical biosensing. SERS‐active PCF probes provide unique opportunity to develop an opto‐fluidic liquid biopsy needle sensor that enables one‐step integrated sample collection and testing for disease diagnosis. Specificity being a key parameter to biosensors, the PCF inside the biopsy needle could be functionalized with targeting moieties to detect specific biomarkers. In this review article, we present some of the most promising recent biosensors based on PCFs including hollow‐core PCFs, suspended‐core PCFs and side‐channel PCFs. We provide a wide range of applications of such platform using Raman spectroscopy, label free SERS or labeled SERS detection and analyze some of the main challenges to be addressed for translating it to a clinically viable next generation sensitive biopsy needle sensing probe. Abstract : Tremendous enhancement factor that surface‐enhanced Raman scattering (SERS) possesses coupled with the flexibility of photonic crystal fibers (PCFs) pave the way to a new generation of ultrasensitive biosensors. This review article aims to provide the latest advancement in SERS‐based PCF sensors for various bio‐chemical applications. Such a sensitive biosensor could be translated for the detection of biomarkers in body fluids for early diagnosis of diseases.