Anemia of inflammation associated with periodontitis: Analysis of two clinical studies. Issue 11 (6th June 2019)

• Record Type: Journal Article
• Authors: Nibali, Luigi; Darbar, Ulpee; Rakmanee, Thanasak; Donos, Nikos
• Is Part Of: Journal of periodontology. Volume 90:Issue 11(2019)
• Page Start: 1252
• Page End: 1259
• Publication Date: 2019-06-06
• Subjects: inflammation and innate immunity -- periodontitis -- periodontal medicine -- periodontal‐systemic disease interactions; Periodontics -- Periodicals; 617.632
• DOI: 10.1002/JPER.19-0124
• Languages: English
• ISSNs: 0022-3492

Abstract

Abstract: Background: While leukocytosis is a common feature of severe periodontitis, a smaller amount of evidence has been produced on erythrocytes counts in periodontitis, suggesting a possible tendency to anemia. The aim of this study was to investigate the associations between periodontitis and circulating leukocytes, erythrocytes, and platelets. Methods: The study included 471 patients with periodontitis (including aggressive periodontitis [AgP], and chronic periodontitis [CP]) and periodontal health. A separate sample of 333 patients from a previous study (127 AgP and 206 periodontally healthy) was used as replication. Periodontal clinical data were collected and a blood sample was obtained from each participant for hematological analysis of leukocytes, erythrocytes and platelets. Results: Adjusted linear regression analyses revealed associations between periodontitis and total leukocytes counts ( p < 0.001), neutrophil counts ( P <0.001) and hematocrit (HCT) levels ( P = 0.045). Sub‐analysis revealed no statistically significant differences between AgP and CP. Disease severity was correlated with total leukocyte and neutrophil counts and HCT ( P <0.001, P <0.001 and P = 0.004, respectively). In the replication sample, adjusted linear regression analysis revealed associations between periodontitis and decreased hemoglobin (HB) ( P = 0.009), mean corpuscular hemoglobin (MCH) ( P = 0.023), and MCH concentration ( P <0.001). A subset of patients included in these studies (14% to 15.7% of periodontitis versus 8.4% to 10.2% of healthy, respectively, in the two cohorts) were anemic based on the World Health Organization criteria. Conclusion: This paper, reporting results of periodontal examination and blood sampling in over 800 patients, suggest that not just leukocytosis but also tendency to "anemia of inflammation" are typical features of periodontitis.