Bacterial resistance to antimicrobial peptides. (21st October 2019)

• Record Type: Journal Article
• Authors: Abdi, Milad; Mirkalantari, Shiva; Amirmozafari, Nour
• Is Part Of: Journal of peptide science. Volume 25:Number 11(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-10-21
• Subjects: antimicrobial peptides -- AMPs -- bacterial resistance -- host defense peptides; Peptides -- Periodicals; Peptides -- Periodicals; 572.65
• DOI: 10.1002/psc.3210
• Languages: English
• ISSNs: 1075-2617

Abstract

Abstract : Antimicrobial peptides (AMPs) or host defense peptides (HDPs) are vital components of human innate defense system targeting human‐related bacteria. Many bacteria have various mechanisms interfering with AMP activity, causing resistance to AMPs. Since AMPs are considered as potential novel antimicrobial drugs, understanding the mechanisms of bacterial resistance to direct killing of AMPs is of great significance. In this review, a comparative overview of bacterial strategies for resistance to direct killing of various AMPs is presented. Such strategies include bacterial cell envelope modification, AMP degradation, sequestration, expelling, and capsule. Abstract : Bacterial cell envelope modification is the main cause of bacterial resistance to Antimicrobial Peptides Many bacterial proteins degrade or sequestrate the AMPs Some bacterial species become resistant to AMPs by expelling them through efflux pumps.