Biological response to peri‐implantitis treatment. (18th July 2019)

• Record Type: Journal Article
• Authors: Bhavsar, Ishita; Miller, Craig S.; Ebersole, Jeffrey L.; Dawson, Dolphus R.; Thompson, Katherine L.; Al‐Sabbagh, Mohanad
• Is Part Of: Journal of periodontal research. Volume 54:Number 6(2019)
• Page Start: 720
• Page End: 728
• Publication Date: 2019-07-18
• Subjects: biomarkers -- crevicular fluid -- dental implants -- peri‐implantitis; Periodontics -- Periodicals; 617.632
• DOI: 10.1111/jre.12681
• Languages: English
• ISSNs: 0022-3484

Abstract

Abstract: Objective: To investigate biological markers of peri‐implantitis (PIP) in crevicular fluid before and after surgical and antimicrobial therapy. Material and Methods: Forty‐eight participants (24 healthy implants and 24 PIP) were clinically evaluated, and peri‐implant crevicular fluid (PICF) samples were collected at baseline for both groups, and at 3‐months after surgical and antimicrobial treatment (ie, n = 21 PIP completers). Samples were analyzed for interleukin‐1β (IL‐1β), matrix metalloproteinase‐8 (MMP‐8), and macrophage inflammatory protein‐1α (MIP‐1α) using immunoassay and the results compared between groups. Results: Peri‐implantitis sites at baseline demonstrated significantly higher mean periodontal probing depths, percentage bleeding on probing ( P ≤ 0.001), and mean IL‐1β concentration in PICF compared to healthy implant sites (17.9 vs 1.7 pg/μL; P = 0.02). Three months after treatment, periodontal probing depths, bleeding on probing, suppuration ( P < 0.05), and the mean concentration of MMP‐8 decreased significantly compared with baseline (12.1 vs 6.7 ng/μL, P = 0.04). MIP‐1α concentrations showed no differences between the groups. Conclusion: Elevated concentrations of IL‐1β in PICF were consistent with PIP. A decrease in MMP‐8 concentration in PICF at three months after treatment is consistent with a healing biological response.