A successful antibiotic treatment by a new administration route: a case report of a subcutaneous administration of ceftazidime and tobramycin. (24th May 2019)

• Record Type: Journal Article
• Authors: Duron, Dorothée; Chanoine, Sébastien; Peron, Maud; Lepelley, Marion; Allenet, Benoît; Epaulard, Olivier; Camara, Boubou; Bedouch, Pierrick
• Is Part Of: Fundamental & clinical pharmacology. Volume 33:Number 6(2019)
• Page Start: 703
• Page End: 706
• Publication Date: 2019-05-24
• Subjects: ceftazidime -- subcutaneous administration -- tobramycin; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/fcp.12477
• Languages: English
• ISSNs: 0767-3981

Abstract

Abstract: When intramuscular or intravenous administrations of parenteral drugs are not possible, the use of other routes (e.g., subcutaneous route) should be considered. We report a patient with Duchenne muscular dystrophy, who was hospitalized for acute pneumonia due to antibiotic‐resistant strains of bacteria. Our patient was successfully recovered with antimicrobial therapy by subcutaneous administration of ceftazidime and tobramycin, for which no safety and efficacy data are available in humans. To the best of our knowledge, this case is the first supporting the subcutaneous administration safety and potential efficacy of both ceftazidime and tobramycin in humans.