Decrypting the communication between microbes and the intestinal mucosa—A brief review on Pathogénie Microbienne Moléculaire's latest research. (30th October 2019)

• Record Type: Journal Article
• Authors: Stedman, Aline; Brunner, Katja; Nigro, Giulia
• Other Names: Pizarro‐Cerda Javier guestEditor.; Tran Van Nhieu Guy guestEditor.
• Is Part Of: Cellular microbiology. Volume 21:Number 11(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-10-30
• Subjects: intestinal microbiota -- intestinal crypts -- intestinal stem cells -- dysbiosis -- CSCM; Microbiology -- Periodicals; Cytology -- Periodicals; Host-parasite relationships -- Periodicals; Microbiology -- Periodicals; Cells -- Periodicals; Microbiologie -- Périodiques; Microbiologie; Relation hôte-parasite; Cytologie; Cellule; Réponse cellulaire; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); 579.05
• DOI: 10.1111/cmi.13118
• Languages: English
• ISSNs: 1462-5814

Abstract

Abstract: Over the past 10 years, the "Pathogénie Microbienne Moléculaire" unit of Professor Philippe Sansonetti has studied the molecular cross talk between the intestinal microbiota and the gut epithelium, aiming to better understand how this mutualistic symbiosis delineates homoeostasis and, when perturbed, prompts pathology. To do so, the unit has manipulated both bacterial and epithelial cells, and used cutting‐edge technology. More recently, the lab has turned its focus also on studying the intestinal crypt and more specifically the intestinal stem cell for their role in epithelial regeneration and long‐term epithelium renewal. Here, we provide a brief review summarising recent results obtained from the lab, with particular focus on the intestinal crypt.