Helicobacter pylori eradication in patients with type 2 diabetes mellitus: Multicenter prospective observational study. (February 2019)

• Record Type: Journal Article
• Authors: Nam, Seung-Joo; Park, Sung Chul; Lee, Sang Hoon; Choi, Dong Wook; Lee, Sung Joon; Bang, Chang Seok; Baik, Gwang Ho; Park, Jong Kyu
• Is Part Of: SAGE open medicine. Volume 7(2019)
• Publication Date: 2019-02
• Subjects: Helicobacter pylori -- diabetes mellitus type 2 -- glycated hemoglobin A; Medicine -- Periodicals; 610.5
• DOI: 10.1177/2050312119832093
• Languages: English
• ISSNs: 2050-3121

Abstract

Objective: To compare Helicobacter pylori ( H. pylori ) eradication rate of type 2 diabetic patients with non-diabetic subjects. Methods: In this multicenter prospective observational study, H. pylori -infected subjects were enrolled from three university-affiliated hospitals. Eradication regimen was triple therapy with standard dose of proton pump inhibitors (b.i.d), amoxicillin (1.0 g b.i.d), and clarithromycin (500 mg b.i.d) for 7 days. Urea breath test was performed 4 weeks after treatment. Various clinical and laboratory data were collected for identification of factors associated with successful eradication. Results: Totally, 144 subjects were enrolled and 119 (85 non-diabetic and 34 diabetic patients) were finally analyzed. Eradication rate was 75.6% and there was no difference between diabetic patients and non-diabetic subjects (73.5% vs 76.5%, p value: 0.814). Adverse drug reactions were reported in 44.5% of patients. In multivariate analysis for predicting H. pylori eradication in diabetic patients, HbA1c (⩾7.5%) was a significant factor affecting eradication rate (adjusted odds ratio: 0.100, 95% confidence interval: 0.011–0.909, p value: 0.041). Conclusion: Diabetes itself is not a major factor affecting H. pylori eradication. However, poor glucose control may harmfully affect H. pylori eradication.