Nanotherapy: Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2 (Adv. Mater. 46/2019). Issue 46 (12th November 2019)

• Record Type: Journal Article
• Authors: Li, Huimin; Guo, Huilin; Lei, Chang; Liu, Li; Xu, Liqin; Feng, Yaping; Ke, Jin; Fang, Wei; Song, Hao; Xu, Chun; Yu, Chengzhong; Long, Xing
• Is Part Of: Advanced materials. Volume 31:Issue 46(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-11-12
• Subjects: drug carriers -- hyaluronic acid -- nanoparticles -- osteoarthritis -- protein delivery; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201970331
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : In article number 1904535, Chun Xu, Chengzhong Yu, Xing Long, and co‐workers report a new strategy to promote endogenous production of hyaluronic acid for the management of osteoarthritis by delivering hyaluronan synthase type 2 into the synoviocytes of joints using biodegradable mesoporous silica nanoparticles. This nanotherapy also helps in the repair of bone defects in a rat osteoarthritis bone‐defect model.