Chronic myelomonocytic leukemia associated with myeloid sarcomas and NPM1 mutation: a case report and literature review. (June 2019)

• Record Type: Journal Article
• Authors: Matanes, Faris; AbdelAzeem, Basel M.A.; Shah, Gaurav; Reddy, Vishnu; Saad, Ayman; Papadantonakis, Nikolaos
• Is Part Of: Therapeutic advances in hematology. Volume 10(2019)
• Publication Date: 2019-06
• Subjects: chronic myelomonocytic leukemia -- myelodysplastic syndrome/myeloproliferative neoplasm -- myeloid sarcoma -- NPM1 mutation; Hematology -- Periodicals; Hematologic Diseases -- therapy -- Periodicals; Hematology -- Periodicals; 616.15005
• DOI: 10.1177/2040620719854596
• Languages: English
• ISSNs: 2040-6207

Abstract

We present a case of chronic myelomonocytic leukemia (CMML) associated with myeloid sarcomas. The CMML also harbored a NPM1 mutation, which is uncommonly described outside the context of acute myeloid leukemia (AML). We describe our treatment strategy, which involved remission-induction chemotherapy that led to rapid resolution of myeloid sarcomas, and we present a literature review highlighting the treatment challenges that similar cases pose.