Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus. (July 2019)

• Record Type: Journal Article
• Authors: Guo, Ke; Li, Li-Li; Zhang, Qing; Yu, Jie-Mei; Ye, Yan
• Is Part Of: Evolutionary bioinformatics online. Volume 15(2019)
• Publication Date: 2019-07
• Subjects: human astrovirus -- quasispecies -- hematopoietic stem cell transplantation -- molecular evolution; Bioinformatics -- Periodicals; Evolutionary computation -- Periodicals; Genetic programming (Computer science) -- Periodicals; Computational Biology; Evolution, Molecular; Bioinformatics; Electronic journals; Periodicals; Fulltext; Internet Resources; Periodicals; Periodicals; 576.8
• DOI: 10.1177/1176934319864922
• Languages: English
• ISSNs: 1176-9343

Abstract

We assessed the quasispecies heterogeneity of a human astrovirus MLB2 (HAstV-MLB2-YJMGK) in immunocompromised patients following hematopoietic stem cell transplantation and performed genetic and evolutionary analyses of HAstV isolates circulating worldwide. The result showed that the virus had diversified variants and a strong positive selection in the patient, indicating that such patients may be a reservoir for astrovirus. The time to the most recent common ancestor of MLB2 and classic HAstVs was around 1800 years, and it has a decline in effective population size of HAstVs in the late 100 years.