The Targeted Therapies Era Beyond the Surgical Point of View: What Spine Surgeons Should Know Before Approaching Spinal Metastases. (16th August 2019)

• Record Type: Journal Article
• Authors: Cofano, Fabio; Monticelli, Matteo; Ajello, Marco; Zenga, Francesco; Marengo, Nicola; Di Perna, Giuseppe; Altieri, Roberto; Cassoni, Paola; Bertero, Luca; Melcarne, Antonio; Tartara, Fulvio; Ducati, Alessandro; Garbossa, Diego
• Is Part Of: Cancer control. Volume 26:Number 1(2019)
• Publication Date: 2019-08-16
• Subjects: bone metastases -- breast cancer -- cancer -- cancer treatment -- colorectal cancer -- lung cancer -- melanoma -- NSCLC -- renal cancer -- lymphoma; Cancer -- Prevention -- Periodicals; Cancer -- Diagnosis -- Periodicals; Cancer -- Treatment -- Periodicals; Cancer -- Palliative treatment -- Periodicals; Cancer -- Prevention; Medical Oncology; Neoplasms -- prevention & control; Neoplasms -- therapy; Electronic journals; Periodicals; Periodicals; 616.994005
• DOI: 10.1177/1073274819870549
• Languages: English
• ISSNs: 1073-2748

Abstract

In the last few years, the treatment of spinal metastases has significantly changed. This is due to the advancements in surgical technique, radiotherapy, and chemotherapy which have enriched the multidisciplinary management. Above all, the field of molecular biology of tumors is in continuous and prosperous evolution. In this review, the molecular markers and new approaches that have radically modified the chemotherapeutic strategy of the most common metastatic neoplasms will be examined together with clinical and surgical implications. The experience and skills of several different medical professionals are mandatory: an interdisciplinary oncology team represents the winning strategy in the treatment of patients with spinal metastases