0952 Factors Accounting For The Relationship Between Osa And Cognition. (12th April 2019)

• Record Type: Journal Article
• Authors: Aron, Adrian; Yoder, Isaac; Barger, Kyle; Brown, Shelby; Capell, Audrey; Cox, Jordan; Ie, Susanti; Pellant, Kathleen
• Is Part Of: Sleep. Volume 42(2019)Supplement 1
• Page Start: A383
• Page End: A383
• Publication Date: 2019-04-12
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsz067.950
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: A common concern in individuals with obstructive sleep apnea (OSA) is impaired cognitive functioning. Because multiple comorbidities are often seen in individuals with OSA, and treatment does not always lead to enhanced cognition, the main contributor of cognitive decline is uncertain. The purpose of this study was to determine the impact of comorbidities on the effectiveness of CPAP intervention and cognitive improvement in individuals with OSA. Methods: We screened 18 OSA patients (AHI = 35.8 ± 21.4) free of cardiovascular diseases and not on any type of substance that can alter cognition. Testing procedures included objective measurements of arterial stiffness using pulse wave velocity (VaSera 1500, Fukuda Denshi, Tokyo, Japan), followed by two cognitive tests to evaluate executive functioning [(Stroop Color-Word Test (SCWT)] and psychomotor speed [Digit Symbol Substitution Test (DSST)]. Assessments were performed at baseline and after 2 and 4 months of CPAP/APAP treatment. Results: Patients had the same weight at two months (101.6 ± 13.4 kg) and four months 102.4 ± 15.5 kg) compared to baseline (105.3 ± 17.0 kg), p = 0.1. Blood pressure was not changed throughout treatment, 138.8 ± 11.8 mmHg vs. 143.0 ± 17.0 mmHg vs 135.3 ± 14.9 mmHg, p = 0.2. Also, cardio-ankle vascular index (CAVI) did not decrease with treatment, 7.7 ± 1.1 vs. 7.2 ± 1.5 vs 7.4 ± 1.7, p = 0.3. Significant improvements in executive functioning were seen at two (39.3 ± 5.1) and four months (40.5 ± 8.6) following CPAP treatment compared to baseline (33.8 ± 5.3). Psychomotor speed improved after four months, 51.0 ± 7.7 vs 46.1 ± 6.9, p = 0.0001. Just one patient had diabetes at baseline, however his status was not reassessed after treatment. Conclusion: Improvement in cognitive function after CPAP intervention was likely not caused by changes in cardiovascular indices, diabetes or weight. This suggests that intermittent hypoxia and sleep fragmentation, when abolished by the CPAP/APAP treatment, are sufficient to improve the cognitive profile in patients with OSA. Support (If Any): N/A