0835 Do Low vs. Normal BMI Subjects Differ with Respect to Sleep Disorders Symptoms?. (12th April 2019)

• Record Type: Journal Article
• Authors: D'Antonio, Breanna; Boyle, Julia T; Vargas, Ivan; Seewald, Mark; Gencarelli, Amy M; Muench, Alexandria; Perlis, Michael L
• Is Part Of: Sleep. Volume 42(2019)Supplement 1
• Page Start: A335
• Page End: A335
• Publication Date: 2019-04-12
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsz067.833
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: It is commonly accepted that high BMI values are associated with a wide range of sleep complaints and/or signs and symptoms of various sleep disorders. In contrast, little is known about the relationship between low BMI values and sleep disturbance. Accordingly, the present study represents an initial inquiry into whether low BMI values are associated with sleep disturbance. Methods: An archival analysis was conducted on an existing database of 4, 206 individuals who completed a screening survey (www.sleeplessinphilly.com ). Low BMI (BMI of <18.5 kg/m 2 ) subjects were identified and matched 1:1 by race, age, and gender to normal BMI controls (BMI of 18.5-24.9 kg/m 2 ). The two groups were compared using unadjusted serial t-tests for differences in sleep continuity disturbances (i.e., SL, NWAK, WASO, TST) problem endorsements (e.g., 'my SL is a problem for me') and on sleep disorder symptom endorsements (e.g., 'I snore'). Results: Overall, the Low-BMI group (N= 58, Female= 65.5%, Age= 39.2 years) did not significantly differ from the Normal-BMI group (N= 58, Female= 63.8%, Age= 40.0 years) for sleep continuity disturbances, problem endorsements, or sleep disorder symptoms. A trend was evident for problem endorsement viz. SL, with more Low-BMI subjects reporting problems with falling asleep than normal BMI subjects (84.9% vs. 69.2%, p = 0.056). For sleep disorder symptoms, there were trends for fewer Low-BMI subjects endorsing snoring (37.9% vs. 50.0%, p = 0.190) and more Low-BMI subjects endorsing restless leg symptoms (35.3% vs. 19.0%, p = 0.189). Conclusion: The data suggest that there may be some differences for viz. problem endorsements and sleep disorders symptoms, between individuals who have Low and normal BMI. Of interest: 1) fewer Low-BMI subjects reported snoring, and this may be taken as evidence of the validity of the present analysis; and 2) more of the Low-BMI subjects reported RLS, and this may be suggestive of iron deficiency, glucose dysregulation, or uremia. More refined queries are likely required to substantiate the observed trends (e.g., questions that better assess RLS/PLMs and/or NES or SRED). Support (If Any): Perlis NIH:R01AG041783;K24AG055602;R01AT003332