0931 Post-Stroke Sleep Duration And Quality Are Associated With Depression. (12th April 2019)

• Record Type: Journal Article
• Authors: Qiu, Emily; Kronish, Ian; Edmondson, Donald; Shechter, Ari
• Is Part Of: Sleep. Volume 42(2019)Supplement 1
• Page Start: A374
• Page End: A375
• Publication Date: 2019-04-12
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsz067.929
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: One in three stroke survivors develop post-stroke depression. Stroke survivors often experience severe disruptions in sleep; additionally, sleep disturbance is a chief complaint in depression. We examined whether sleep duration and quality in the month following a stroke is associated with the development of post-stroke depression. Methods: The Reactions to Acute Care and Hospitalization (REACH)-Stroke study is an observational cohort study examining how environmental, psychosocial, and behavioral factors relate to long-term health outcomes following stroke/transient ischemic attack (TIA). Sleep duration, quality, and the use of sleep medications following hospital discharge were assessed at 30-day follow-up with 3 questions based on the Pittsburgh Sleep Quality Index. At 6 months, patients completed the 8-item Patient Health Questionnaire depression scale (PHQ-8). Binary logistic regression was conducted, producing adjusted odds ratios (OR) on the association between 1 month short sleep duration, bad sleep quality, or use of sleep medications, with depression at 6 months, controlling for age, sex, race/ethnicity, and baseline depression. Results: The current analysis included 236 patients (age: 63.0 ± 14.5 y, 49% female). Short sleep (<6 h/night) in the month following stroke was reported 30.9% of patients. Poor sleep quality (rating of sleep as fairly or very bad) and use of medication for sleep (at least once per week) were reported in 24.6% and 17.4% of patients, respectively. Depression at 6 months was reported in 16% of patients. The presence of depression at 6 months post-stroke was significantly associated with short sleep vs. non-short sleep (adjusted OR=2.83, 95% CI: 1.31-6.11), poor sleep quality vs. good sleep quality (adjusted OR=4.01, 95% CI: 1.80-8.93), and use of sleep medication vs. no use (adjusted OR=4.72, 95% CI: 1.91- 11.64) during the month following stroke. Conclusion: Short sleep duration, poor sleep quality, and use of sleep medication during the 1-month following stroke were all associated with depression 6-months post-stroke. Since depression is associated with worsened functional recovery, prevention and/or treatment of poor sleep should be prioritized following a stroke to encourage optimal psychological and physiological health. Support (If Any): R01HL141494