Magnetically Actuated SiCN‐Based Ceramic Microrobot for Guided Cell Delivery. Issue 21 (9th October 2019)

• Record Type: Journal Article
• Authors: Gyak, Ki‐Won; Jeon, Sungwoong; Ha, Laura; Kim, Sangwon; Kim, Jin‐young; Lee, Kwang‐Sup; Choi, Hongsoo; Kim, Dong‐Pyo
• Is Part Of: Advanced healthcare materials. Volume 8:Issue 21(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-10-09
• Subjects: biocompatible materials -- cell delivery -- ceramic microrobots -- magnetic nanoparticles -- silicon carbonitride; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201900739
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: A silicon carbonitride (SICN) ceramic microrobot, biocompatible and magnetically activable, is developed for the delivery of viable cells to defective tissue by sequential steps of microstructuring, magnetization, and cell loading. The ceramic carrier of porous cylindrical framework is fabricated by 3D laser lithography using a photocurable preceramic polymer, chemically modified polyvinylsilazane, and subsequent pyrolysis at 600 °C under an inert atmosphere. Magnetic nanoparticles (MNP) are integrated into the surface‐modified ceramic carrier by thiol‐ene click reaction. Finally, the microrobot is loaded with fibroblast cells, which can be guided by a rotating external magnetic field. The proposed ceramic microrobot is mechanically durable, adequately controllable with external magnetic field, and quite compatible with mammalian cells. Abstract : Biocompatible magnetically actuated silicon carbonitride ceramic microrobots are developed for biomedical applications. The microrobots are fabricated by 3D laser lithography using a photocurable preceramic polymer and converted to ceramics by subsequent pyrolysis. Magnetic nanoparticles are integrated onto the surface for magnetic actuation. The microrobots loaded with fibroblast cells are actuated with directionality by an external magnetic field.